To be honest, I don't really see your point. You say that authors 'need' to think about the reactions of those outside of their intended audience, but you haven't offered any reasons other than that it might be offensive to some people. While causing offense isn't nice, the effect on the author's commercial success is likely to be pretty minimal, since the work wasn't targeted at those audiences anyway.
Worrying about offending people is one of the quickest ways to stifle your ability to express yourself, as you mention with your satire example. As long as you are not deliberately constructing your text to cause offense to or promote prejudice against a person or group, it seems far more useful to simply write whatever you want and take any constructive criticism on board for your next work (or not, if you don't feel the need to improve as an author).
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Worrying about offending people is one of the quickest ways to stifle your ability to express yourself, as you mention with your satire example. As long as you are not deliberately constructing your text to cause offense to or promote prejudice against a person or group, it seems far more useful to simply write whatever you want and take any constructive criticism on board for your next work (or not, if you don't feel the need to improve as an author).