Wicked good thought-provoking post. I've been trying to figure out where the portrayal of people with OCD in Xenocide by Orson Scott Card might go. Without getting overly spoilery, the people with OCD (the 'god-spoken') are actually in the leadership role on said colony, but are hindered by the compulsive ritual process, which is seen as a spiritual honour despite the frustration and pain they cause.

It's weird, and I'm angry at him for so many other reasons, but I will give OSC credit for writing the most accurate description, on an emotional level, of what OCD feels like.

Also, I can't help but think of The Speed of Dark and Flowers for Algernon as being like but also unlike Behold The Wonders Of Modern Science, being as they do examine (problematically or not) the personal effects of a 'wonder cure'.