Under 'disability superpower', I can't help but think of Ghost in the Shell. Motoko has a completely artificial body, and her co-workers vary from almost totally cyborg to completely human (aside from the cyber-brains that all but the poorest members of society seem to have). The series touches on both class and disability issues--those on the lower rungs of society can't afford the high-end prosthetics. And while some choose to go cyborg for the advantages, others wind up that way after being disabled--including Motoko herself.

There also some trade-off issues. For one, cyborg bodies are harder to control--Motoko at one point mentions that as a child, she broke a doll because of her poor control. They're also higher maintenance, and cyborgs have different dietary requirements. And of course, the whole cyberbrain thing allows for things like hacking into people's minds.